Safe for all 100% Food Grade Silicone, BPA-free and PVC-free. Soothing for baby; safe and soft on baby's gums while teething. Knotted between beads for added safety. Can be handwashed with mild soap or cleaned in the top shelf of any dishwasher. Signature Itzy Ritzy logo bead and/or breakaway clasp. Each unit is packaged in an individual box.